Thyroid Cancer Clinical Trials Intelligence
Monthly Update Report for Trials Started in May 2026
Powered by Sophic Starlight
Sophic does not practice medicine nor provide medical advice. The Sophic Starlight Cancer Clinical Trials Intelligence Report is provided for educational and consulting purposes only. This report is not a substitute for professional medical advice, diagnosis, or treatment. Sophic shall not be held responsible for any interpretation, application, or use of this report beyond these purposes.
The Sophic Starlight Cancer Clinical Trials Intelligence Report is intended solely as an educational resource that provides access to publicly available clinical trial data integrated within Sophic’s proprietary knowledgebase and summarized with AI. Reports are provided entirely free of charge, and patients should never be billed or charged for access to this information. Users agree to reference Sophic in any publication, presentation, or publicity that incorporates or relies upon information from Sophic Starlight Cancer Clinical Trials Intelligence Reports.
1: Summary data from new trials identified for Thyroid Cancer.
Overview
Number of Trials: 2
Both trials focus on improving patient engagement and decision-making in low-risk differentiated thyroid cancer care. One trial evaluates health and wellness coaching to enhance patient activation and adherence to healthy habits post-thyroidectomy. The other assesses a patient-facing decision aid to reduce decision anxiety and improve readiness for treatment choices in newly diagnosed patients.
Common Criteria Across Trials
Common Inclusion
- Adults aged 18 years or older
- English proficiency or English-speaking
- Low-risk or differentiated thyroid cancer (papillary or follicular)
- Ability to provide informed consent
Common Exclusion
- Medullary or anaplastic thyroid carcinoma
- History of thyroid cancer or thyroid surgery
- Cognitive or psychiatric impairment precluding participation
- Currently pregnant
2: Extracted Trials with New Information
Trials with Special Criteria
Unique or Unusual Criteria
- NCT07545837 — Requires status post total thyroidectomy, levothyroxine monotherapy only, and TSH less than 4 uIU/mL at 3 months post-surgery
- NCT07536412 — Excludes patients who have already consulted a surgeon about their thyroid nodule or cancer
Trials with Emerging Treatments
- NCT07545837 — Health and Wellness Coaching to Improve Patient Activation and Adherence to Healthy Habits in Differentiated Thyroid Cancer Care: A Mixed-Methods Pilot Study
Items: Counseling
Note: Counseling intervention tailored to thyroid cancer patients for informed decision-making on treatment options, sourced from web search - NCT07536412 — Efficacy of a Patient-facing Decision Aid in Reducing Decision Anxiety and Improving Decision Readiness in Low Risk Thyroid Cancer
Items: Decision Aid
Note: Patient-facing decision aid designed to reduce anxiety and improve decision readiness in low-risk thyroid cancer, sourced from web search
3: Individual Trial Overviews
NCT07545837
Health and Wellness Coaching to Improve Patient Activation and Adherence to Healthy Habits in Differentiated Thyroid Cancer Care: A Mixed-Methods Pilot Study
Organization/Sponsor: Mayo Clinic
Example patient: A 45-year-old English-speaking adult with papillary thyroid carcinoma who completed total thyroidectomy and radioactive iodine therapy six months ago, currently on levothyroxine monotherapy with TSH of 2.5 uIU/mL and no cognitive impairments.
Phase N/A
NCT07545837
Health and Wellness Coaching to Improve Patient Activation and Adherence to Healthy Habits in Differentiated Thyroid Cancer Care: A Mixed-Methods Pilot Study
Organization/Sponsor: Mayo Clinic
Example patient: A 45-year-old English-speaking adult with papillary thyroid carcinoma who completed total thyroidectomy and radioactive iodine therapy six months ago, currently on levothyroxine monotherapy with TSH of 2.5 uIU/mL and no cognitive impairments.
Interventions
-
Behavioral: Questionnaire Administration
Summary: Patient self-reported outcome tool assessing quality of life and treatment effects through structured questionnaires, measuring psychological and physical impacts (NCI Thesaurus, Web Search). -
Behavioral: Interview
Summary: Qualitative method gathering patient-reported outcomes through conversations about treatment experiences, preferences, and personal details to inform trial endpoints (NCI Thesaurus, Web Search). -
Behavioral: Counseling
Summary: Educational intervention supporting informed decision-making for thyroid cancer treatment through discussions and materials clarifying therapy benefits and risks (Web Search).
Key Inclusion
- Adults ≥ 18 years
- Histologically confirmed papillary or follicular thyroid carcinoma
- Status post total thyroidectomy ± radioactive iodine therapy
- Receiving levothyroxine monotherapy
- TSH < 4 uIU/mL at ≥ 3 months post-thyroidectomy
- English proficiency
Key Exclusion
- Medullary or anaplastic thyroid carcinoma
- Current systemic therapy for thyroid or other cancers
- Cognitive or psychiatric impairment precluding participation
- Inability to complete study procedures
NCT07536412
Efficacy of a Patient-facing Decision Aid in Reducing Decision Anxiety and Improving Decision Readiness in Low Risk Thyroid Cancer
Organization/Sponsor: University of Maryland, Baltimore
Example patient: A 42-year-old English-speaking woman newly diagnosed with a low-risk papillary thyroid microcarcinoma on biopsy, with no prior thyroid surgery or cancer history, not pregnant, and has not yet consulted a surgeon.
Phase N/A
NCT07536412
Efficacy of a Patient-facing Decision Aid in Reducing Decision Anxiety and Improving Decision Readiness in Low Risk Thyroid Cancer
Organization/Sponsor: University of Maryland, Baltimore
Example patient: A 42-year-old English-speaking woman newly diagnosed with a low-risk papillary thyroid microcarcinoma on biopsy, with no prior thyroid surgery or cancer history, not pregnant, and has not yet consulted a surgeon.
Interventions
-
Behavioral: Decision Aid
Summary: An educational intervention providing information on treatment options and discussion questions to help low-risk thyroid cancer patients make informed choices, reduce anxiety, and improve decision-making readiness (Source: Web Search).
Key Inclusion
- Low-risk thyroid cancer or thyroid nodule suspicious for malignancy
- English-speaking
Key Exclusion
- Prior consultation with surgeon regarding the thyroid nodule or cancer in question
- Cancer or nodule has high risk features (e.g. extrathyroidal extension on ultrasound)
- History of thyroid cancer
- History of thyroid surgery
- Currently pregnant (per patient report)